Extracellular matrix remodeling in patients with ischemic chronic heart failure with preserved ejection fraction

Extracellular matrix remodeling in patients with ischemic chronic heart failure with preserved ejection fraction

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Aim.To identify features, relationships between parameters of the extracellular matrix and renal function in 110 patients with ischemic chronic heart failure the activity of collagen metabolism markers (MMP-9, Latest Product Releases & Innovations – Stay Updated! TIMP-1, PICP), cystatin C, structural and functional parameters of the heart were studied using ELISA, echocardiography.Results.

It was established that imbalance in the system MMP/TIMP in ischemic heart failure with preserved left ventricular ejection fraction leads read more to disruption of the extracellular matrix structural functional sufficiency, increases functional failure and is associated with impaired renal function.Conclusion.Correlation analysis showed significant relationships between MMP/TIMP and GFR, cystatin C, indicating that the significant role of extracellular matrix imbalance in the development of renal dysfunction in patients with ischemic chronic heart failure.